Coave Therapeutics is a genetic medicines company based in Paris that develops technologies to improve genetic medicine delivery. Its proprietary ALIGATER™ platform is designed to enhance targeting, specificity, efficacy and manufacturability of genetic medicines. The company is focused on overcoming gene therapy delivery challenges to extra-hepatic tissues and is building a pipeline targeting CNS, neuromuscular and eye diseases. Led by CEO Rodolphe Clerval, Coave positions ALIGATER as a platform with broad clinical applications. The company raised €32M in a Series A to advance the ALIGATER platform. Emmanuelle Coutanceau from Novo Holdings and Jean Francois Morin from Bpifrance will join Coave’s board of directors in connection with the financing. Coave Therapeutics develops targeted genetic medicines using its proprietary ALIGATER™ platform, which chemically modifies AAV capsids or lipid nanoparticles to improve efficacy, safety, and manufacturability. The company’s conjugated vectors (coAAV) enable targeted delivery to the central nervous system and the eye, achieving improved transduction and biodistribution across species at low doses. Its lead disclosed program in the article, CTx-TFEB, is a coAAV-delivered TFEB gene therapy designed to promote autophagy and clear toxic protein aggregates in neurons as a potential pan-ALS treatment. Coave recently received grant funding from the ALS Association to advance CTx-TFEB through preclinical proof-of-concept and aims to establish robust preclinical data to support a clinical transition. The company is headquartered in Paris, France and states its pipeline targets both rare and prevalent neurodegenerative and ocular indications. Coave is backed by unnamed international life sciences investors mentioned in the company description. Coave Therapeutics is a clinical-stage biotech advancing gene therapies for rare ocular and CNS diseases using its AAV-Ligand Conjugate (ALIGATER) platform. Its lead candidate, CTx-PDE6b, is a first-in-class AAV-based gene therapy designed to deliver a full-length functional PDE6b gene for PDE6b-associated retinitis pigmentosa and is currently in a Phase I/II trial. The company has entered a licensing and co-development partnership with Théa Open Innovation to advance CTx-PDE6b through clinical development and commercialization in Europe and adjacent territories. Under the agreement Coave will co-develop the program with Théa and share development costs while retaining commercialization rights outside the partner territories, including the US. Financially, Coave will receive an upfront payment and an equity investment of €10 million and is eligible to receive up to €65 million in development, regulatory and commercial milestone payments, plus double-digit royalties on net sales in licensed territories. Coave is headquartered in Paris and is backed by investors including Seroba Life Sciences, Théa Open Innovation, eureKARE, Fund+, Omnes Capital, V-Bio Ventures, Kurma Partners, Idinvest, GO Capital and Sham Innovation Santé/Turenne. Coave Therapeutics, led by CEO Rodolphe Clerval and based in Paris, is advancing targeted gene therapies using its AAV-Ligand Conjugate (ALIGATER) platform to enhance AAV delivery and transduction. The company is progressing a pipeline that includes the lead clinical program CTx-PDE6b, currently in a Phase I/II trial, and preclinical candidates such as CTx-GBA1 (Parkinson’s disease and Gaucher disease) and CTx-ABCA4 (Stargardt’s disease). Coave will use proceeds to push CTx-PDE6b toward pivotal trials, further develop the ALIGATER platform, advance new preclinical coAAV programs in rare CNS and ocular diseases, and seek partnerships to accelerate clinic entry. The company is clinical-stage and focused on producing targeted gene therapy products via proprietary chemical conjugation of AAV vectors. Financially, the company has raised a total of €33.1M following the Series B expansion.

Total raised

$77M

Funding rounds

4

Latest round

Series A

Latest activity

Jan 2025