Congruence Therapeutics is a clinical-stage biotechnology company that uses a computationally driven discovery engine, Revenir, to identify allosteric and cryptic pockets and generate novel small-molecule correctors. Its lead program, CGX-926, is advancing toward a Phase 1/1b study for MC4R-deficient genetic obesity, and the recent $39.5M financing is earmarked to support that trial. The company has built a pipeline of wholly owned programs spanning genetic obesity, GBA Parkinson’s Disease, and α1‑Antitrypsin Deficiency. Congruence also leverages its platform to support research collaborations with large pharmaceutical companies across oncology, metabolic disease, neurology, and immunology. The company is led by CEO Dr. Clarissa Desjardins and is based in Montreal.

Total raised

$87M

Funding rounds

3

Latest round

Equity

Latest activity

Mar 2026