Nucleix is a liquid biopsy company based in San Diego and Rehovot, Israel, developing methylation-based tests for earlier cancer detection. Its core platform, EpiCheck®, detects DNA methylation changes and is compatible with both NGS and PCR workflows. The company uses NGS for deep biomarker discovery and plans to advance sensitive, cost-effective PCR tests that can run in centralized and local labs. Its lead product, Lung EpiCheck, is a blood assay being developed to detect lung cancer early in current and former smokers. Nucleix also markets Bladder EpiCheck in Europe for bladder cancer recurrence. Clinical data on the first generation of Lung EpiCheck was published in October 2020, and the company is developing an improved assay and planning a prospective validation study. The recently secured financing will fund further advancement and validation of Lung EpiCheck toward planned availability in 2022. Nucleix develops, manufactures and markets innovative, non-invasive molecular cancer diagnostic tests. The company is advancing Lung EpiCheck™, a blood screening test for early detection of lung cancer based on proprietary molecular biomarker technology. Lung EpiCheck combines new biochemical assays and algorithms to identify and analyze subtle changes in DNA methylation patterns to distinguish cancer from healthy cells. Led by CEO Opher Shapira, PhD, Nucleix intends to use recent funding to accelerate development of Lung EpiCheck. The company is based in Rehovot, Israel. Investors in the company include OrbiMed and other investors. Nucleix Ltd. develops, manufactures and markets non-invasive molecular cancer diagnostic tests that identify subtle changes in DNA methylation patterns. Its technology combines a novel biochemical platform with algorithmic analysis to detect cancer-associated methylation signals. The first product, Bladder EpiCheck®, is a urine test for monitoring bladder cancer and was expected to reach the market in Q3 2016. The company's pipeline includes blood-based diagnostic tests for lung and colorectal cancer. Nucleix raised $3M in funding to continue advancing its tests and to hire new staff. Backers on this round include OrbiMed Israel Partners, Aurum Ventures MKI and Zohar Zisapel.

Total raised

$61M

Funding rounds

3

Latest round

Equity

Latest activity

Apr 2021