The Venture Codex

Participated · Seed · Feb 2026

Entirety Biomedical is a Michigan-based medical device startup creating absorbable metal implants that offer titanium-like strength during healing and then safely resorb once bone union is achieved. Its patented Curasorb alloy underpins plate-and-screw and headless compression screw systems aimed initially at lower-extremity and maxillofacial procedures, allowing surgeons to avoid permanent hardware without changing existing surgical workflows or reimbursement models. The company completed its first preclinical study in 2024 and is running three additional preclinical studies, with early data showing strong osseointegration. These studies will guide a planned first-in-human clinical trial of its lower-extremity headless compression screw system. Entirety works closely with surgeons and strategic partners to identify unmet fixation needs and translate them into products that improve patient outcomes and reduce secondary removal surgeries. Founded by materials-science engineers Jake Edick and Carolyn Woldring, the team brings more than a decade of absorbable magnesium R&D experience and multiple related patents. The startup recently secured $1.2 million in seed funding to advance product development toward clinical trials.