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The Venture Codex

Frist Cressey Ventures

40 Burton Hills Blvd Ste 370, Nashville, Tennessee, 37215, United States

Overview

Frist Cressey Ventures is focused on accelerating the growth of high potential healthcare enterprises through value-added partnerships. We invest in technology and service businesses with viable solutions that improve quality of care, system integration, patient outcomes, and population health and wellbeing. We join like-minded entrepreneurs who share similar core values in their pursuit to improve healthcare.

Total investments
44
Lead investments
16
Investments · 12mo
8
Active investors
4

Sector focus

  • Business Development
  • Health Care
  • Venture Capital
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Investment portfolio

  • Knit Health

    Led · Seed · May 2026

    Knit Health develops an AI infrastructure layer and a Large Clinical Behavior Model (LCBM) that learns from real-world clinician decision-making patterns using behavioral cloning and causal inference. Its LCBM is trained on EMR data from over 130 million patients across 30 U.S. health systems. The company focuses on automating complex care routing, triage, and discharge predictions to optimize clinical operations and patient care pathways. Knit Health is a UC Berkeley spin-out led by co-founder and CEO Jonathan Kolstad and is based in San Francisco, California. It has achieved full HIPAA compliance and is actively partnering with major U.S. health systems to deploy initial models for automated patient flow and quality improvement. The recent seed funding is intended to accelerate further development and deployment of its models across health systems.

  • Modicus Prime

    Led · Equity · May 2026

    Modicus Prime provides a Trustworthy AI Compliance Software platform that integrates with pharmaceutical tech stacks and quality management systems to create a single source of truth for AI compliance across the full lifecycle. The platform is designed to make AI applications in GxP environments audit-ready for pharmaceutical companies, CROs, CMOs, CDMOs and adjacent regulated sectors, and to translate between data science, IT, quality and compliance functions. Modicus Prime says its platform supports biologics, cell and gene therapies, and vaccine manufacturing across global regulatory environments including FDA and EMA requirements. Leadership has contributed to industry guidance—CEO Taylor Chartier co-authored the ISPE GAMP AI Guide and BioPhorum AI Implementation publication and led ISPE's GxP AI Webinar Series—positioning the company as an active participant in regulatory and educational initiatives. The company is using recent funding to expand customer support and continue platform enhancements to better support deployments and growing AI compliance needs. Modicus Prime was formerly a resident at Johnson & Johnson Innovation – JLABS @ Texas Medical Center and is currently associated with JLABS @ South San Francisco.

  • Qualified Health

    Participated · Series B · Mar 2026

    Qualified Health provides a secure enterprise AI platform and strategic services to help health systems deploy AI with embedded safety, governance, and monitoring. Its platform combines workflow automation, agent development, clinical safeguards, real-time monitoring, and end-to-end traceability. Early deployments with partners including Mercy, Emory Healthcare, University of Rochester Medicine, Jefferson Health, and the University of Texas System have produced measurable revenue uplift and cost savings, including more than $15 million in run-rate impact at UTMB within six months. The platform currently supports more than 500,000 users across health systems representing approximately 7% of U.S. hospital revenue. The company is led by former health system executives, frontline physicians, clinical transformation experts, and Silicon Valley engineers. Qualified Health plans to deepen partnerships and scale its platform responsibly while expanding governance, monitoring, and infrastructure to support mission-critical AI deployments.

  • Chamber Cardio

    Led · Series A · Feb 2026

    Chamber Cardio is building the infrastructure needed for cardiologists to thrive under value-based care contracts. Its workflow-native platform ingests cardiology data and uses artificial intelligence to flag high-risk patients, identify gaps in guideline-directed therapy, and cut down on manual chart review. These insights are paired with operational support aimed at reducing preventable complications and hospital utilization while improving patient experience and giving payers clearer visibility into total cost of care. The company already partners with multiple health plans and works with more than 500 cardiologists across seven states. Fresh capital will be deployed to deepen health-plan and practice partnerships, enter additional markets, and grow Chamber’s clinical, operational, and technology teams. Following its $60 million Series A, backed by leading health-tech investors, Chamber is positioned to accelerate national expansion in a market where cardiovascular disease remains one of the largest drivers of U.S. healthcare spending.

  • One to One Health

    Led · Equity · Jan 2026

    One to One Health delivers onsite and virtual primary care services for employers, universities, and health plans, combining human clinicians with an AI-enabled platform called Intelligent Care Manager that supplies real-time clinical intelligence at the point of care. The company’s model emphasizes high engagement and member satisfaction while lowering total cost of care. Its footprint currently spans more than 650 organizations and reaches over 500,000 members nationwide. Revenue figures were not disclosed, but the scale of its membership base underscores meaningful market traction. Looking ahead, management plans to deepen adoption of its advanced primary care model across the United States. A core part of those plans is continued enhancement of Intelligent Care Manager to further automate and personalize clinical workflows. By integrating technology and care delivery, One to One Health aims to expand access, improve outcomes, and reduce healthcare costs for large distributed workforces.

Team