Hopelab
100 California Street, Suite 1150, San Francisco, CA, 94111, United States
Overview
Hopelab is a social innovation lab and impact investor advancing entrepreneurs, research, digital health, and solutions that support and empower young people, especially those from historically underserved communities. The organization works to remove systemic barriers to youth mental health and emotional well-being through targeted social impact investments, hands-on design and research support for digital innovation, and translational science partnerships. Learn more at hopelab.org.
- Total investments
- 10
- Lead investments
- 1
- Investments · 12mo
- 2
- Active investors
- 3
Sector focus
- Health Care
- Impact Investing
- Mental Health
- Non Profit
- Social Impact
- UX Design
- Venture Capital
Investment portfolio
- Flourish Health
Participated · Series A · Jul 2026
Flourish Health delivers intensive in-home mental health care for children and young adults through psychiatrist-led Care Pods composed of a child and adolescent psychiatrist, a licensed therapist, a patient guide, and a family guide. The company built a proprietary technology platform that integrates patient touchpoints, EMR and prescribing capabilities, workflow automation, team collaboration, and AI to support engagement and coordination while clinicians make clinical decisions. Flourish specializes in three clinical populations: children with externalizing behaviors, young people with multiple suicide attempts or suicide-related hospitalizations, and patients with complex needs and family situations often turned away by other clinics. Studies run with multiple major health plans report large reductions in hospitalization (70–96%), residential treatment (69–90%), and sustained decreases in higher levels of care post-discharge (80–95%). Flourish commits to beginning care within one week of referral, reports 92% month-over-month retention during its 12-month programs, and says those programs cost less than one month of inpatient treatment.
- Nest Health
Participated · Series A · Nov 2025
Nest Health delivers integrated medical, behavioral, and social care to entire households, replacing the fragmented experience of juggling pediatric, adult, and mental-health providers. Families receive age- and stage-aligned in-home visits augmented by virtual consultations, 24/7 clinical support, and coordinated referrals to specialists. The company’s offering spans primary care, mental-health and substance-use treatment, and social-needs assistance such as housing or utilities support. Its AI tools automate workflows before, during, and after caregiver interactions to boost care-team efficiency. Founded by Dr. Rebekah Gee, Nest Health currently operates in Louisiana and Arizona and targets Medicaid populations. The fresh $22.5 million Series A financing strengthens its balance sheet and will fund expansion of its AI-driven clinical products and geographic footprint through new and existing payer partnerships.
- Backpack Healthcare
Participated · Series A · May 2024
Backpack Healthcare (formerly Youme Healthcare) operates an online pediatric mental-health platform that combines an AI-powered emotion-monitoring app with live teletherapy delivered by licensed clinicians. The company’s algorithms assess mood signals and automatically match young users to therapists who specialize in their needs, creating individualized treatment plans. Beyond one-on-one pediatric sessions, Backpack offers family therapy, medication management, and live parent-training webinars covering topics such as cyberbullying and substance abuse. Interactive digital tools and gamified activities are used to keep children engaged and encourage consistent participation in care. With its newly secured capital, management plans to enhance the technology stack, broaden geographic reach, and deepen its teletherapy service portfolio. Equity and inclusion remain a stated priority, underscored by the addition of Robert Johnson, ESQ, to the advisory board to guide inclusive growth initiatives.
- InStride Health
Participated · Series B · Mar 2024
InStride Health delivers virtual specialty outpatient care for pediatric anxiety and obsessive-compulsive disorder using cognitive behavioral therapy with a focus on exposure therapy. It provides multidisciplinary care teams—typically a therapist, an exposure coach and a psychiatrist—that develop personalized care plans and communicate with patients and families via text, phone or video. The company serves patients ages seven to 24 and currently operates in 17 states, having treated more than 5,000 patients. Reported outcomes include 97% of graduates showing overall clinical improvement and over 99% of patients remaining out of the hospital one year after discharge. Caregiver impacts reported include an 81% reduction in caregiver stress and more than 90% reporting reduced missed work. InStride aims to expand access to evidence-based specialty care while preserving its clinical outcomes as it grows into new and existing markets.
- Vytyl Health Management
Participated · Series A · Jan 2024
Vita Health delivers clinically validated suicide-prevention care management via telehealth, and also offers teletherapy and psychiatry for broader behavioral health conditions. Its care pathways are based on the founding team’s clinical trials published in JAMA and The American Journal of Psychiatry and thousands of patient encounters. Those trials and encounters demonstrated reductions in suicide attempts by more than 60% and deaths by up to 80%. The company was founded by a consortium of suicide risk experts and behavioral health innovators and has expanded its mission to address the youth mental health crisis, including anxiety and depression. Vita Health is building relationships with health plans, provider partners, employers, colleges, and universities to expand access. The company plans to use new funding to support rapid nationwide expansion of its life-saving services for youth and adults.