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The Venture Codex

Main Street Advisors

120 N LaSalle St Suite 3300, Chicago, IL, 60602, United States

Overview

Main Street Advisors provides equity, fixed income, investment planning, asset allocation strategies, investment management, environmental, social, client asset management, and governance services.

Total investments
12
Lead investments
3
Investments · 12mo
3
Active investors
1

Sector focus

  • Financial Services
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Investment portfolio

  • MOSH

    Led · Series A · May 2026

    Co-founded in 2021 by Maria Shriver and Patrick Schwarzenegger, MOSH positions itself as The Brain Brand® offering functional nutrition primarily in bar format. Its protein bars are formulated with a MOSH Signature Brain Blend anchored by Cognizin® Citicoline and include ingredients such as lion's mane, ashwagandha, omega-3s, and vitamins B12 and D3. MOSH reports distribution in 2,000+ U.S. retail doors and is preparing a nationwide Target launch alongside placements at Sprouts, Albertsons, Kroger, and HEB. The company is expanding its product line with MOSH High Protein, a bar featuring 20 grams of protein, creatine, and the Signature Brain Blend. MOSH directs a portion of proceeds to Alzheimer's research and women's brain health, having raised more than $400,000 and funded three research grants to date. Recent funds from the Series A will be used to scale retail distribution, advance product innovation, support a new research grant, and build marketing, sales, and supply chain capabilities.

  • Wolf Games

    Led · Series A · Oct 2025

    Wolf Games develops a generative AI platform that produces “living, cinematic gaming universes” which adapt storylines, characters, and worlds to individual players in real time. Unlike other AI content tools, the company positions its engine as a creative partner that preserves story logic and character integrity while scaling narrative game creation. Its first universe, Public Eye, will enter beta later this year, inviting players to act as detectives in a crime-filled modern world with daily, choice-driven storylines. Wolf Games has also inked a partnership with NBCUniversal to explore immersive games that expand popular studio IP, an alliance driven by the startup’s emphasis on ethical AI and respect for storytellers. Founded by writer-producer Elliot Wolf and tech entrepreneurs Andrew Adashek and Noah Rosenberg, the company is backed by notable entertainment figures including Dick Wolf, Jimmy Iovine, and Paul Wachter. Headquarters are in Los Angeles, California. Financial details beyond its recent Series A have not been disclosed, and no user or revenue metrics were provided.

  • Pelage Pharma

    Participated · Series B · Oct 2025

    Pelage Pharmaceuticals is a regenerative-medicine biotechnology company focused on first-in-class treatments for hair loss in both men and women. Its science centers on stem cell biology and metabolism, aiming to restore the body’s natural ability to grow hair by reactivating dormant hair-follicle stem cells. The company’s lead asset, PP405, is a non-invasive topical small molecule currently being evaluated in Phase 2a clinical trials. Proceeds from the most recent financing will be directed toward advancing PP405 through mid-stage development and expanding Pelage’s broader pipeline of hair-regeneration therapies. Led by CEO Daniel Gil, Ph.D., Pelage’s leadership team includes co-founder and President William Lowry, Ph.D. The firm has also strengthened its governance, appointing Cathy Friedman (GV) as Board Chair and adding Richard Heyman, Ph.D. (ARCH) to its board. The fresh capital positions Pelage to accelerate clinical progress and prepare for later-stage studies.

  • Horizon Surgical Systems

    Participated · Series A · Oct 2024

    Horizon Surgical Systems develops Polaris, an assistive microsurgical robotics platform that combines state-of-the-art robotics, advanced medical imaging, and AI to extend surgeons' capabilities in eye surgery. The company positions Polaris to improve consistency, speed, and outcomes while enhancing access to care through augmented visualization and precision robotic control. Proceeds from its $30M Series A will advance Polaris development, fund progression to first-in-human studies, and support team expansion. Horizon emphasizes automated, AI-enabled robotics to push the boundaries of surgical precision in ophthalmology. The company was founded in 2021 as a spin-out from UCLA and is based in Malibu, California.

  • StatusPro

    Participated · Series A · Feb 2024

    StatusPRO develops sports training and gaming products that fuse data with augmented, mixed, and virtual reality to create immersive experiences for coaches, players, and fans. Its core product lineup includes NFL PRO ERA, an NFL and NFLPA‑licensed first‑person VR simulation launched in 2022 that gives users a professional player’s perspective. The NFL PRO ERA franchise recently added head‑to‑head multiplayer gameplay and featured Lamar Jackson as its cover athlete. The company was founded and developed by former football players Troy Jones and Andrew “Hawk” Hawkins and is based in New York City and Miami. StatusPRO plans to broaden development into new sports titles while continuing to enhance modes, features, and its underlying technology. The company raised outside funding and intends to deploy proceeds toward product expansion and technical improvements. StatusPRO provides a suite of training and gaming products that combine player data with augmented reality (AR) and virtual reality (VR). Its training platform uses real-time player data to power holographic experiences that let players simulate any practice or game scenario without the physical impact of playing. Players are able to simulate virtual practice sessions while in different locations to mitigate the effects of having less time on the field. The company plans to leverage its platform to expand into the gaming market. StatusPRO said it will use the recently raised funds to accelerate expansion of products aimed at reshaping how players and coaches prepare for games and to define new forms of engagement between athletes and fans. The company was co-founded by Andrew "Hawk" Hawkins and Troy Jones and is based in Miami, FL.

Team