Twine Ventures
765 South Van Ness Avenue, San Francisco, California, 94110, United States
Overview
Twine Ventures is an early-stage venture capital firm that focuses on human health, climate, and financial empowerment. The firm was founded by Leshika Samarasinghe in 2021 and is based in San Francisco, California, United States.
- Total investments
- 12
- Lead investments
- 0
- Investments · 12mo
- 5
- Active investors
- 1
Sector focus
- Financial Services
- Health Care
- Software
- Venture Capital
Investment portfolio
- CloudCruise
Participated · Seed · Mar 2026
CloudCruise provides a three-part infrastructure for healthcare AI agents: a coding agent that generates automation scripts, fully managed infrastructure to run those scripts at scale, and a maintenance agent that keeps automations working as portals and EHRs change. The product targets complex, multi-step healthcare workflows such as prior authorization, eligibility verification, and EHR note creation that require interacting with web portals like a human. The company participated in Y Combinator's Winter 2024 batch and is headquartered in San Francisco. Founders are Adrian Ziegler and Felix Eckert, and CloudCruise has raised $5M in seed funding from institutional investors and angels. The firm is hiring to expand its team and scale its managed infrastructure.
- Rowspace
Participated · Seed · Feb 2026
Rowspace offers an AI system that links financial organizations’ memos, models, and legacy accounting data to generate real-time insights inside familiar tools such as Excel and Microsoft Teams. The platform is designed to be deployed within a customer’s own environment, safeguarding proprietary information while codifying institutional judgment for tasks like portfolio monitoring, credit optimization, and long-horizon deal analysis. Led by CEO Michael Manapat, former CTO of Notion, and COO Yibo Ling, a two-time CFO, the company operates out of San Francisco and New York. Rowspace claims to already serve institutions overseeing nearly a trillion dollars in assets, demonstrating early traction among large asset managers. With fresh capital, the team plans to accelerate engineering and research hiring across both offices and deepen development of its finance-specific AI models. The company’s strategy centers on becoming the operating layer for institutional decision-making by embedding AI directly into existing workflows. Financially, it has secured $50 million across seed and Series A rounds to fund these ambitions.
- Alaffia Health
Participated · Series B · Feb 2026
Founded in 2020 by siblings TJ Ademiluyi and Adun Akanni, Alaffia Health offers a platform that pairs expert clinicians with transparent, traceable AI to scrutinize claims against complete patient records across payment integrity, utilization management, and appeals workflows. The software delivers 97%+ accurate clinical fact extraction and has produced 20%+ average savings on high-cost facility claims and 5x+ ROI for health plans, saving partners more than $100 million to date. Customers report turnaround times shrinking from weeks to days while maintaining compliance and provider-relations standards. With growing pressure on payers to lower medical and administrative costs, the company positions itself as foundational infrastructure that scales clinical review capacity. The newly raised capital will fund R&D, launch additional AI agents, and expand engineering, product, and growth teams. Alaffia operates as a SaaS or managed-services partner to regional and national health plans and is headquartered in New York.
- Oasys
Participated · Seed · Jan 2026
Oasys offers a cloud-based, AI-powered platform that automates core behavioral-health workflows such as documentation, scribing, billing, scheduling, and insurance reimbursements while integrating physiological data from wearables like Apple Watch, Oura Ring, Strava, and Flo. By combining administrative automation with continuous biometric insight, the system aims to reduce clinician burnout, surface early risk signals, and support more personalized, measurable therapy. The company already partners with more than 25 health clinics, serving hundreds of providers and thousands of patients nationwide, and it is onboarding new clinics within 48 hours each week. Early users report measurable gains in patient engagement, higher symptom-tracking compliance, fewer claim denials, and faster reimbursements. Thousands of therapy sessions have been logged on the platform since launch, demonstrating early traction. Looking ahead, Oasys plans to roll out a robust outcomes-measurement framework in 2026 and expand its partner network to over 1,000 enterprise-scale mental-health organizations. The recent $4.6 million in funding will be used to deepen product integrations, grow engineering and data-science teams, and broaden partnerships across clinics, MSOs, universities, and schools.
- Ava
Participated · Seed · Oct 2025
Developer of a consumer financial platform designed to improve credit scores and reduce interest rates for American consumers. The company's app offers a rewards-based credit builder card, installment loans, cash flow-based underwriting, automatic payments, and detailed financial analysis, enabling users to increase on-time payments and lengthen their overall credit history.
Team
Leshika Samarasinghe
Founder and General Partner
LinkedIn