The Venture Codex Logo

The Venture Codex

VentureSouth

101 N Main St Ste C15, Greenville, SC, 29601, United States

Overview

VentureSouth is an early-stage venture firm that develops and manages angel investment groups and funds throughout the Southeast. Since our inception with the Upstate Carolina Angel Network in 2008, VentureSouth has grown to include more than 550 investors across a dozen angel groups and funds, making us one of the largest angel investment organizations in the United States. To date, VentureSouth has deployed over $80 million in more than 100 companies. Follow us to learn how we Make Money. Have Fun. Do Good.

Total investments
23
Lead investments
8
Investments · 12mo
1
Active investors
5

Sector focus

  • Finance
  • Venture Capital
Visit website

Investment portfolio

  • StratusGrid

    Participated · Seed · Jun 2026

    StratusGrid builds Stratusphere, an AI-driven services platform that discovers cloud optimization opportunities, plans and routes approvals, supports execution of approved changes, monitors results, and verifies savings in complex AWS and Azure environments. The company emphasizes closing the loop from visibility to verified outcomes by enabling safe, approved execution of infrastructure changes so engineering teams can stay focused on feature delivery. StratusGrid reports that its approach has helped customers save millions of dollars in large-scale cloud environments and is particularly focused on private equity-backed software companies. The business was bootstrapped prior to raising its $3 million seed and is now using the financing to accelerate product development, grow engineering capacity, and scale go-to-market efforts. StratusGrid is headquartered in Chattanooga, Tenn., and positions Stratusphere as an AI-native execution layer for cloud optimization.

  • mPath Health

    Participated · Equity · Mar 2024

    mPATH Health develops a digital cancer‑screening program that integrates automation and behavioral science to drive preventive care. The company says its program has demonstrated the ability to double screening rates across diverse populations regardless of race, ethnicity, income, or literacy level. mPATH plans to expand its screening and preventive health modules and to conduct additional rigorous clinical testing supported by grant funding. The platform emphasizes personalized outreach to identify, educate, and ensure timely access to relevant screenings, with a stated commitment to health equity. The recent funding is intended to accelerate growth, expand reach, and document return on investment for health systems and insurers. mPATH Health integrates automation and behavioral science to improve preventive cancer screening. Led by CEO and Founder Dr. Dave Miller, the company uses plain language, engaging animations, and video testimonials to inform, motivate, and empower individuals to request and complete evidence-based screenings. mPATH is currently in use across three healthcare systems in North Carolina for colorectal and lung cancer screening, and a fourth major healthcare system will launch the program in March. The company raised $1.1M consisting of $706K in angel investments and $400K from a National Cancer Institute Small Business Technology Transfer grant. mPATH plans to use the funds to develop new modules for other preventive care needs, add artificial intelligence to guide its outreach, and accelerate its growth trajectory.

  • Yuva Biosciences

    Led · Seed · Feb 2024

    Yuva Biosciences applies AI to mitochondrial research to identify compounds that restore mitochondrial function; its first ingredient to market is YuvaBio® Y100™. Y100 is available for licensing to non-drug consumer brands and is being incorporated into BosleyMD’s Revive Plus Densifying Foam for national retail and e-commerce rollout. The company was founded in 2019 and is headquartered in Birmingham, Alabama. Yuva’s scientific leadership includes Co‑Founder and CSO Dr. Keshav K. Singh and CEO Greg Schmergel; the team also includes consumer-products veteran Dr. Shekhar Mitra. The company reports noticeable effects in multiple clinical trials and positions the platform to target additional mitochondrial-related indications such as ovarian aging and wound care. Financially, Yuva completed a $7.5M seed financing led by VentureSouth.

  • Trio Labs

    Participated · Series A · Jan 2024

    Trio Labs builds ultra high-resolution metal additive-manufacturing technology to produce micro parts (targeting ~5 micron resolution) for medical devices and microneedle applications. The company sells finished micro components rather than 3D printers and focuses on taking customers from R&D design files through volume production. Trio targets large medtech segments including minimally invasive surgical devices and microneedles, and cites sub-markets such as U.S. diabetes care. Traction includes nine customers — many household names — who have submitted design files; Trio expects to begin generating revenue before the end of the year. The team is building manufacturing infrastructure in 2022 and plans to use Series A proceeds to scale production and develop strategic partnerships. Trio is pursuing extensive IP protection, filing global patents in 10 jurisdictions with a goal of building a large patent portfolio to support exit options.

  • Gradient Health

    Participated · Equity · Jun 2023

    Gradient Health operates a secure, unified platform that gives researchers and developers access to raw and labeled medical images needed to train and validate AI technologies. The company offers machine-learning-ready formatting, searchable access by disease and imaging modality, and tools to facilitate compliant research and seamless collaborations. It emphasizes state-of-the-art security measures to protect patient privacy and ensure regulatory compliance. Gradient Health collaborates with academic institutions, healthcare organizations, and technology partners to advance medical knowledge and improve patient care. Led by CEO Josh Miller, the company recently raised $2.75M and intends to use the proceeds to continue assembling its comprehensive annotated medical imaging library.

Team