
Waterline Ventures
44 Brattle Street, 1st Floor, Cambridge, MA, 02138, United States
Overview
Waterline is a group of longtime healthcare investors who partner with amazing entrepreneurs tackling the healthcare industries toughest problems. Waterline Ventures invests in the early stage healthcare technology and services companies that are improving the way care is delivered. Increasing costs, inconsistent quality, and inadequate access to healthcare create the need for innovation. Companies that address these issues stand to create tremendous value while improving people's lives across the country and around the world. There is a massive and growing opportunity for technological transformation in healthcare. Their entrepreneurs are leading the change within healthcare.
- Total investments
- 26
- Lead investments
- 8
- Investments · 12mo
- 2
- Active investors
- 3
Sector focus
- Health Care
Investment portfolio
- Kinomatic
Led · Seed · Jun 2026
Kinomatic offers an end-to-end platform that spans pre-operative 3D modeling, VR surgical simulation, post-operative recovery optimization, long-term outcomes tracking, and concierge-level patient care for knee and hip replacements. Its AI analyzes over two million data points from more than 1,000 measurements per patient to select optimal matches from over 30,000 possible implant configurations. The company emphasizes biomechanical precision to improve prosthesis sizing accuracy, shorten operative time, and accelerate functional recovery. Kinomatic reported 7x revenue growth over four years, a 5x increase in provider relationships, and an NPS of 85. Founded in 2021, the company recently added Dr. Andrew B. Wickline as Chief Medical Officer to enhance post-operative recovery protocols. Kinomatic plans to use new funding to expand headcount, open a new office, and continue developing its AI-enabled surgical planning and recovery technology.
- CVRD Health
Participated · Seed · May 2026
CVRD Health provides a platform that gives federal contractors real-time visibility into benefit obligations, spend, and reimbursement status so fringe dollars are recovered and compliance is maintained. The platform pairs financial transparency with full benefits administration using an Individual Coverage Health Reimbursement Arrangement (ICHRA) and assigns each employee a dedicated member advocate for plan selection and ongoing support. CVRD says contractors using the platform recover 100% of benefits spend and stay compliant with SCA, DBRA, and prevailing wage requirements. The company serves federal contractors nationwide and highlights a customer, Aptive Resources, which saved over $500,000 in its first year, reduced average premiums by 52%, and cut monthly employer contributions by 30%. CVRD is headquartered in Miami, Florida and positions itself as the only fringe benefit optimization and compliance platform built exclusively for government contractors.
- SimpliFed
Participated · Equity · Feb 2025
SimpliFed offers virtual breastfeeding and baby feeding support and broader maternal health care from pregnancy through the postpartum period via a secure, HIPAA-compliant telehealth platform. The company connects parents with a network of baby feeding experts and maternal health specialists and operates a proprietary Maternal Health operating system designed for collaboration with healthcare partners. Its platform uses interoperable infrastructure and API-driven technology to integrate with health plans, providers, partners and health systems for secure data exchange and streamlined workflows. SimpliFed intends to expand those partnerships and scale use of its Maternal Health OS following its Series A. The company is led by founder and CEO Andrea Ippolito and is based in New York City. The recent Series A raised over $10M to support platform growth and partner activation.
- Persimmon
Participated · Equity · Aug 2024
Persimmon is a telemedicine platform focused on delivering aesthetic cosmetology services at home. The company offers on‑demand aesthetic and cosmetic medical services performed in customers’ residences. Founders reported significant revenue growth year over year. Persimmon generated $750,000 in revenue in 2022 and $4.8 million in 2023. The company’s current business model and any future product plans were not detailed in the article. The valuation in the latest round was not disclosed.
- Ventricle Health
Participated · Seed · Oct 2023
Ventricle Health operates a national virtual cardiology care network that connects patients with virtual, guideline-directed medical therapy (GDMT), remote patient monitoring, education and advocacy. The company offers virtual and home-based clinical services and can provide cardiology appointments from patients' homes in as little as three days. Its care model is anchored around established GDMT pathways and integrates remote monitoring and patient education to manage heart failure. Ventricle Health works with Accountable Care Organizations (ACOs), primary care practices and payer partners to deliver value-based cardiology services. The company is currently operating in the Mid-Atlantic, Texas, Ohio and Florida and plans to announce additional markets in the near term. It intends to scale its heart failure management therapeutic model in collaboration with value-based care provider groups and payers.