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Wellcome Trust

215 Euston Road, London, NW1 2BE, United Kingdom

Overview

Wellcome Trust is a medical research charity that funds research that aims to protect and improving human and animal health. It focuses on the fields of public engagement, investments, innovation, humanities, and social science. It was founded in 1936 and headquartered in London, England.

Total investments
44
Lead investments
14
Investments · 12mo
4
Active investors
10

Sector focus

  • Biotechnology
  • Health Care
  • Medical
  • Non Profit
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Investment portfolio

  • Ineffable Intelligence

    Participated · Seed · Apr 2026

    Ineffable Intelligence is a startup that was the subject of media coverage after announcing a $1.1 billion Seed round at a $5.1 billion valuation. The raise was characterized as historic in size for a seed-stage financing. Public reporting did not describe the company's products, services, or core technology. The articles also did not provide operating metrics such as revenue or user counts. No information about the company's founding year, location, or future plans was included in the coverage.

  • Wysa

    Led · Grant · Feb 2026

    Wysa develops evidence-based digital mental-health interventions that have been validated in peer-reviewed research and deployed across public health systems worldwide. The company is now spearheading a scale-up study focused on adapting its programme for adolescent girls living in rural India, a demographic that experiences disproportionately high levels of anxiety, depression, and access barriers. Working with academic and community partners in both the UK and India, Wysa will first investigate cultural and contextual obstacles before co-designing content that reflects the girls’ lived realities. The adapted product will then be evaluated for clinical efficacy and real-world delivery in low- to middle-income contexts. This initiative aims to offer an accessible, relevant, and effective mental-health tool for one of the world’s largest adolescent populations. The project is funded by a £5.3 million grant from Wellcome, giving Wysa substantial non-dilutive capital to expand its reach. The article does not disclose revenue, user numbers, or other operating metrics.

  • System

    Led · Equity · Dec 2025

    System is building knowledge infrastructure that shifts decision-making from siloed data to systems thinking. Its core product, the System Graph, is a patented, large-scale statistical graph that models millions of quantitative relationships across disciplines and is updated daily from trusted evidence sources. Today, System’s APIs are already used by leading healthcare providers in the United States and Europe to power clinical decision support systems. The company is committed to open data and open science, guaranteeing free access to its data and promoting systems literacy. With new funding, System plans to release snapshots of the System Graph into the commons beginning in 2026, develop open-source tools for researchers, and convene an annual conference on systems-based solutions. As a Public Benefit Corporation, System has pledged to maintain its mission-driven charter for at least five more years under its latest investment agreement.

  • Neurocentrx

    Led · Seed · Sep 2025

    Neurocentrx is pioneering what it says will be the first abuse-deterrent oral ketamine prescription, pairing a novel capsule formulation with proprietary digital prescription software to enable a regulated clinic-to-home care pathway. The company targets severe mood disorders, initially treatment-resistant major depressive disorder (TR-MDD) and treatment-resistant bipolar depression (TR-BPD). Its digital platform is designed to bolster patient safety, provider communication and adherence, creating a scalable model for ketamine-based and future therapies. Headquartered in the UK with operations in the US and Australia, Neurocentrx leverages global clinical research expertise. The firm has just secured a seed extension round that delivers over $5 million to advance its clinical programmes. Proceeds will fund a proof-of-concept Phase 2 trial in TR-BPD beginning in Q1 2026. Management is now pursuing a Series A round to finance Phase 2 and Phase 3 trials in TR-MDD, underscoring the capital requirements typical of late-stage psychiatric drug development.

  • Generate

    Participated · Equity · Jul 2021

    Generate builds, owns, operates and finances sustainable infrastructure across energy, waste, water and transport, offering an Infrastructure-as-a-Service model so customers avoid large capital commitments. The company partners with more than 40 technology and project developers and serves over 1,000 customers. Over the last seven years it has built a portfolio of about $2 billion in sustainable infrastructure assets and now owns and operates more than 2,000 assets globally. Generate says its assets are expected to prevent over 43 million metric tons of CO2e over their operating lives. The company recently doubled staff across business lines, launched a Generate Credit unit to create more credit solutions for green projects, and is pursuing geographic expansion beyond North America. The new capital infusion will support expansion into new sectors and regions and continued deployment of proven decarbonization and resource-efficiency solutions. Generate builds, owns, operates, and finances sustainable infrastructure for industry and municipalities across energy, waste, water and transport. Its technology stack includes battery storage, solar, energy efficiency, electric vehicles, fuel cells, wastewater treatment, distributed desalination and organic waste management. The company works with more than 25 development partners to serve hundreds of companies, schools, cities and non-profits throughout North America. Generate plans to grow its fleet of renewable infrastructure projects using recently secured capital. Founded in 2014, the firm has built more than $1 billion in sustainable infrastructure assets. The company reported positive cash flows since its first year and netted more than $100 million in 2019.

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