
National Science Foundation
401 Dulany Street, Alexandria, VA, 22314, United States
Overview
National Science Foundation (NSF) is an independent federal agency that supports research and education in science and engineering. It provides up to $1.5 million in non-dilutive funding to startups working in various areas of science and technology to support research and development (R&D) and mitigate technology risks for commercial success. This funding is part of America's Seed Fund, which is mandated by Congress through the Small Business Innovation Research (SBIR) program. The NSF operates with a budget of approximately $7.8 billion and funds fundamental research and education across all fields of science and engineering.
- Total investments
- 63
- Lead investments
- 37
- Investments · 12mo
- 2
- Active investors
- 9
Sector focus
- EdTech
- Environmental Engineering
- Government
- Internet of Things
- Market Research
- Medical Device
- Nanotechnology
- Robotics
Investment portfolio
- Illuminant Surgical
Participated · Seed · Apr 2026
Illuminant Surgical develops the Skylight platform, which overlays real-time anatomy directly onto a patient to improve procedural precision and streamline workflows. Skylight combines two proprietary technologies: SkinMatch, a non-invasive patient tracking system using adhesive SkinDots and computer vision to align medical images to anatomy in real time; and LightScreen, a depth-adaptive projection system that displays anatomical details on the patient’s skin. The company is led by co-CEOs Dr. James Hu and Eldrick Millares and is based in Los Angeles, CA. Illuminant Surgical recently raised $8.4M in seed funding to accelerate Skylight’s launch. No revenue, user, or prior funding metrics were disclosed in the articles.
- 4Thought Technologies
Led · Grant · Sep 2025
Founded in May 2021 in New York, 4Thought Technologies is developing KRONOS®, a Turing-complete no-code platform that lets finance professionals design and audit smart contracts through a visual, voice-enabled interface. The system converts flow-chart style logic into executable code, providing explainable AI reasoning and blockchain analysis without the need for scarce blockchain engineers. Initial use cases span trading workflows, tax calculations, audit processes, and compliance alerts, with an enterprise pilot already underway at TLW Capital Management. The company positions its technology as a way for banks, asset managers, consultancies, and government agencies to automate complex financial tasks at lower cost and greater speed. To date, it has secured $725,000 in pre-seed equity capital and a $256,000 NSF SBIR Phase I grant, giving it over $981,000 in total non-dilutive and equity funding. Proceeds are earmarked for refining the visual programming language, expanding the KRONOS® feature set, and pursuing a potential Phase II NSF grant. Management argues that regulatory pressure to read and write smart contracts is creating urgent demand for its solution.
- Princeton Critical Minerals
Led · Grant · Aug 2025
Princeton Critical Minerals develops and commercializes an integrated technology platform for extracting lithium from brine, including products named Lilypad™, SmartPond™, and E-LiTE™. The company is operating field deployments that produce validation data under industrial conditions. With the new financing, PCM plans to scale manufacturing and expand commercial deployments while building U.S.-based production capabilities. The firm aims to continue advancing its core extraction technologies toward full commercial execution. The company also reported growth in its team as it prepares to execute on upcoming milestones.
- Auxilium Health
Participated · Seed · Apr 2025
Auxilium Health builds an engineered Aer™ biomaterial platform of bioaerogels intended to resist bacterial attachment while welcoming regenerative cells. The platform spans applications in wound repair, bone regeneration, and localized delivery, with a lead product advancing toward FDA clearance and planned first-in-human studies. The company has attracted researchers and doubled its full-time team over the last year, with several staff relocating to Cleveland. It is headquartered at the Cleveland Clinic's Global Innovation Center and has support from the National Science Foundation, the Ohio Department of Development, and the Polymer Industry Cluster. Financially, Auxilium recently completed an oversubscribed $3.4 million seed round that more than doubled its prior pre-seed financing.
- Rubi Laboratories
Led · Grant · Dec 2024
Rubi Laboratories develops an enzyme-driven platform that converts captured carbon dioxide into cellulose suitable for lyocell and viscose. The process uses a cascade of engineered enzymes in aqueous reactors sized to fit inside shipping-container modules, producing white cellulose within minutes as CO2 is added. Rubi has used AI and machine learning to improve enzyme efficacy and stability and plans to move toward continuous production. The company is building a demonstration-scale system intended to produce tens of tons of material and intends to supply apparel and other industries that use cellulose. Rubi has tested its material with 15 pilot partners, including H&M, Patagonia, and Walmart, and has booked more than $60 million in non-binding off-take agreements with a couple of partners. Leadership includes co-founder and CEO Neeka Mashouf, who founded the company with her twin sister Leila.