25Madison
817 Broadway, 7th Floor, New York, NY, 10003, United States
Overview
25madison is an early-stage venture platform: working with entrepreneurs to build companies from the ground up and investing in pre-seed to series A startups. The platform is comprised of 4 segments: (i) General studio: Builds companies across verticals (ii) 25m health: Builds and invests in healthtech startups in partnership with LifePoint Health (iii) Ventures fund: Invests in pre-seed to series A startups focused on B2B SaaS, fintech, and healthtech (iv) 25m create: Brand and experience agency with services including brand strategy, visual identity, experience design, and web & digital marketing
- Total investments
- 20
- Lead investments
- 5
- Investments · 12mo
- 3
- Active investors
- 9
Sector focus
- Consumer Applications
- Consumer Software
- FinTech
- Health Care
- Incubators
- Venture Capital
Investment portfolio
- Century Health
Participated · Seed · May 2026
Century Health develops the Century Health Abstraction & Retrieval Model (CHARM), an AI-powered platform that automates identification, curation, and enrichment of fragmented clinical data into research-ready real-world evidence. CHARM has achieved 97% accuracy when validated against clinical expert judgment. Over the past year the company grew its specialty provider data network 60x, spanning neurology, nephrology, ophthalmology, respiratory, metabolic, and immunology, and counts multiple Top 5 pharma companies as partners. Century Health is continuing to expand its disease-specific registry network, deepen pharma collaborations, and advance CHARM for complex abstraction and data harmonization. The company raised a $5M seed round to scale collaborations, grow its provider network, and expand its AI-powered data curation infrastructure.
- Ranger AI
Participated · Seed · May 2026
Ranger AI builds an autonomous software infrastructure that deploys specialized AI agents trained on each organization’s technical blueprints to manage workflows from Inquiry to Order for complex RFPs, Order to Remittance, and technical and commercial bid evaluations. The platform is designed to replace manual, fragmented workflows across the industrial revenue cycle and has been deployed on more than 1,000 projects. Customers cited in the article include Celeros Flow, Farabi Petrochemical, MRP Solutions, and Pace Solutions, and the company reports accelerating tendering timelines by up to 50% for those users. Led by founder and CEO James Zhan and based in San Francisco, Ranger AI plans to broaden platform deployment across legal, engineering, and commercial workflows and to expand its engineering team. The company’s immediate financial plan includes using the newly raised seed capital to advance its agentic operating system and scale deployments.
- Miravoice
Participated · Seed · Apr 2026
Miravoice builds an agentic AI platform that conducts automated phone surveys and voice interviews that sound natural, respond in real time and work across languages. Its AI interviewer handles long-form, quantitative surveys—some exceeding 120 questions and lasting over 40 minutes—and supports open-ended responses, numerical inputs, multiple choice, Likert scales and matrix questions. The platform is designed to collect insights at scale without human interviewers. Miravoice is based in San Francisco and is led by CEO Nishant Jain, CTO Danny D. Leybzon and COO & President Shreyas Tirumala. Following its $6.3M seed round, the company plans to expand operations and advance its development efforts using the new capital.
- Ovasave
Led · Seed · Aug 2025
Ovasave, founded in 2023 and based in Abu Dhabi, provides a digital-first platform for women’s fertility and hormonal health. Its offerings include at-home hormone testing, virtual consultations, tailored supplement plans, and coordinated access to leading fertility clinics for egg freezing. The startup also operates a growing corporate benefits program and runs public-education initiatives, including a 2024 “Fertility Your Way” campaign with Merck KGaA that provided free AMH screenings to over 500 women. Ovasave plans to launch in Saudi Arabia this summer and pursue wider MENA expansion over the next three years. The company will use recent funding to accelerate corporate partnerships and to roll out the next phase of its mobile app—adding menstrual cycle tracking, symptom monitoring, integrated care access, and AI-powered treatment plans—and to expand support for perimenopause and menopause. The team notes regulatory fragmentation and cultural nuances across MENA as operational challenges while emphasizing a mission to shift care from reactive treatment to proactive support.
- Handspring Health
Participated · Series A · Jun 2025
Handspring Health operates a virtual mental health clinic focused on youth and young adults, employing clinicians trained in evidence-based modalities such as CBT, DBT and exposure therapy and providing mandatory ongoing clinical supervision and training. The company treats patients across a spectrum of acuity, including a complex care program for high-risk youth, and has treated more than 4,000 patients across nine states. Handspring reports revenue growth of more than 10x over the past two years and clinical outcomes including 93% of families reporting improvement at discharge, 81% of patients treated for anxiety showing clinically meaningful improvement, and 78% for depression. Over 95% of sessions are covered by insurance and the business is in-network with major commercial insurers like BlueCross BlueShield, Aetna, Cigna, UnitedHealthcare, Oscar and Optum. Handspring acquired Joon Care to expand services and in-network coverage in Washington State and plans to scale geographically, deepen payer partnerships, expand parent coaching and continue investing in its AI-enabled technology platform.