
Queen City Angels
4555 Lake Forest Dr Suite 650, Cincinnati, OH, 45242, United States
Overview
Queen City Angels (QCA) is a group of experienced, accredited investors committed to accelerating the growth of early-stage businesses in the Cincinnati area and the surrounding region, via smart investments capable of producing a substantial return.
- Total investments
- 24
- Lead investments
- 7
- Investments · 12mo
- 2
- Active investors
- 9
Sector focus
- Business Development
- Venture Capital
Investment portfolio
- BRANDRANK.AI
Led · Seed · Jul 2026
BrandRank.AI provides an Answer Engine Optimization (AEO) SaaS platform focused on measuring brand visibility, vulnerability, and content readiness in AI-generated answers. The company combines automated recommendations across content, search, reputation, product claims, and advertising strategy with hands-on client support and has expanded into AI-assisted content creation through its acquisition of Averi. Its roadmap includes capabilities for accuracy verification, anti-hallucination monitoring, brand risk alerts, a Brand Health Index, and enterprise trust analytics geared toward agentic AI systems. In just over two years the company has worked with nearly 100 brands and organizations, joined the NVIDIA Inception Program, and was named Nestlé Canada's 2026 Startup of the Year; it was also named a Representative Vendor in Gartner's 2026 Market Guide for Answer Engine Visibility Tools. Key customers cited include Nestlé, Procter & Gamble, Goodwill International, National Public Media, Kroger, Mars, the American Medical Association, and Better Business Bureau chapters. The company intends to use the new seed proceeds to accelerate enterprise growth, expand delivery and vertical solutions, and integrate Averi to move customers from insight to execution across AI answer engines.
- Alphyn Biologics
Led · Series B · Dec 2025
Alphyn Biologics is a clinical-stage dermatology firm advancing first-in-class Multi-Target Therapeutics based on its Zabalafin Platform. Its lead product, Zabalafin Hydrogel, is designed to simultaneously address the multiple drivers of atopic dermatitis (inflammation, itch, bacteria and dry skin) and molluscum contagiosum virus (virus, itch, inflammation, dermatitis and secondary bacterial infection). The topical candidate aims to provide superior efficacy, better tolerability and the potential for sustained disease control compared with single-target treatments. With the new funding, Alphyn plans to run a global Phase 2b trial in atopic dermatitis, launch a Phase 2 program in molluscum contagiosum and scale its raw-material supply. The company became operational in 2020 and maintains offices in Annapolis, Maryland and Cincinnati, Ohio, with subsidiaries in Australia and Austria. Including the latest round, Alphyn has raised roughly $34 million to date to build a pipeline of dermatologic therapeutics.
- 1Logtech
Participated · Seed · Apr 2025
1Logtech offers a no-code integration platform as a service (iPaaS) designed to simplify connectivity across transportation and logistics systems. The platform enables logistics professionals to connect TMSs, ERPs, WMSs, 3PLs, carriers, and shippers using EDI or APIs while providing advanced workflow and business intelligence capabilities, including real-time compliance notifications for carriers. The company is positioning an AI-powered iPaaS enhancement to increase automation and productivity. 1Logtech plans to use the new funding to support product development, expand its team, and accelerate go-to-market efforts. The company intends to deepen its presence across key logistics segments such as truckload, LTL, final mile, and 3PL/trucking-to-customer integrations. Financially, 1Logtech secured a $1.5 million seed round to fund these initiatives.
- Trinity Guardion
Led · Series B · Nov 2024
Trinity Guardion develops hospital bed hygiene solutions anchored by the Soteria Bed Barrier, an FDA-cleared microbiological barrier that protects mattresses from patient soiling. Its Soteria Ecosystem integrates RFID technology and automation with cloud-based software to manage bed-barrier inventory and reprocessing workflows. The system provides bulk scanning, automated workflow assistance, and real-time reporting metrics to streamline tracking between hospital departments and laundry facilities. The company positions its software as data-driven bed reprocessing that ensures clean barriers are ready when needed and helps validate usage. Trinity Guardion plans to use newly raised capital to accelerate production and commercialization of the Soteria Bed Barrier. The company is led by Founder and CEO Bruce Rippe and is based in Cincinnati, OH.
- SureImpact
Participated · Seed · May 2023
SureImpact provides a cloud-based software platform for the social-good ecosystem that enables mission-driven organizations to manage casework, measure outcomes, and produce reports. Led by founder and CEO Sheri Chaney Jones, the platform combines case management, impact measurement, and reporting to support service delivery, community engagement, and fundraising. It leverages a collaborative data model to provide coordinated data collection and shared measurement infrastructure across social-good networks, connecting direct service providers, funders, and other stakeholders. In the last three years adoption has risen to nearly 2,000 users tracking outcomes for more than 90,000 individuals enrolled across initiatives. The company intends to use the funds to continue innovating its solution. SureImpact is based in Columbus, Ohio.